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GSH could detoxify heterogeneous substances under the catalysis of Glutathione S-transferases (GST), then secrete them via the multidrug resistance associated proteins (MRPs) efflux pump (Kuermanbayi et al., 2022)

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Excluding cases with unknown gender, the rate of AEs reported by male patients (58.5%) was higher than that by female patients (30.4%)

Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)